Synchrotron radiation in cancer diagnostics
Ioana Bradeanu Nesoddtangen Tue syöpätutkimusta

Synchrotron radiation in cancer diagnostics

Between 3% and 35% of cancer deaths could be avoided through screening. In X-ray diffraction of hair, most of the particles go straight through and a few particles are deflected by the alpha-keratin that makes up the hair fiber. They end up interfering with each other and causing a distinctive diffraction pattern. We observe images with a circle in the middle and a whole lot of arcs around it. The arcs reflect the spacing of the molecular structures of the hair. Up to now, the biological mechanism explaining the changes in the diffraction patterns was unknown. Recently work, emphasize the hypothesis that cathepsins are released systemically by tumors before is clinically observed and leave the molecular ‘signature’ in alpha-keratin and collagen. We need to conduct more research with a sensitivity of 100% and a specificity of 99.1% in over 4500 patient samples for cancer diagnosis should be sufficient to prove this technique works. Suitable beamlines are necessary to investigate the high volume of the patient sample. Synchrotron X-ray fiber diffraction analysis is a reliable, sensitive and cost-effective method as well as a fantastic tool for a cancer diagnostic. Synchrotron X-ray fiber diffraction analysis could replace the very costly blood tests presently in use for the gene test.

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Target: 500 €
Period:
4/27/2019 5/26/2018

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Ioana Bradeanu
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